V2.1 (version history)

Welcome to CanVar-UK, the interactive database for variant interpretation in cancer susceptibility genes

New to CanVar-UK? Start here!
Check out our introductory video which explains:

  • What CanVar-UK is
  • How to search for a variant
  • What resources are available
  • How to register for membership
  • How to use the diagnostic user forum
New CanVar features

  • A diagnostic user forum for sharing classifications, data, and forum email communication
  • A custom tool for applying the PM5 criterion of the ACMG guidance
  • Gene summary-level data, including CanVIG-UK classification guidance and exon start/end positions
  • Gene-based links to cBioPortal, an external cancer variant database
General CanVar features

  • Data from functional, splicing and genetic epidemiology studies
  • Results from various protein and splicing impact in silico tools
  • Live links to ClinVar
  • Data from control series such as gnomAD
  • Observation frequency in cases from UK diagnostic laboratories

Our resources are mostly available without registration; however, registering for CanVar-UK membership grants additional access to our diagnostic user forum, where members can post questions and/or email out to the CanVar-UK diagnostic user community, as well as view variant-level discussions and provisional classifications.

Registration is available to anyone whose work involves or relates to clinical diagnostics. During your registration, please include details about your institution and your role, and sign up using your work email address.

If you are an NHS scientist or clinician, please register with your NHS email address and your registration will be automatically approved. For other users, there may be a short wait while the CanVar-UK team reviews your application.

For general enquiries, feedback, or suggestions for new gene-specific or pan-gene resources/studies, please contact CanVIG@icr.ac.uk.
For variant-specific information, papers or resources, please create a post on the diagnostic user forum page for that variant.

The Cancer Variant Database is a repository of annotations for variants in cancer predisposition genes only.
The information on CanVar-UK is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Information displayed on CanVar-UK has not been independently verified.